Effect of immunoadjuvants on the disease course in patients with operable breast cancer
https://doi.org/10.17650/1994-4098-2018-14-4-20-23
Abstract
Background. A new strategy of breast cancer management is required for effective disease prevention and control. Immunotherapy is one of promising options.
Objective: to evaluate the effect of immunoadjuvant polyoxidonium on pathmorphological changes in breast tumors.
Materials and methods. The study was performed in 75 patients with breast cancer: 50 patients received polyoxidonium in a neoadjuvant regimen (main group), 25 patients did not receive polyoxidonium (control group). Polyoxidonium at a dose of 12 mg was administered intramuscularly 1 time per day on the days 1, 2, 3, 5 and 7 before surgery; on the day 8, radical mastectomy was performed in patients of both groups, followed by histological examination and determination of the grade of therapeutic pathomorphosis of the tumor.
Results. The proportion of cases with grade I therapeutic pathomorphosis was 58 %, grade II therapeutic pathomorphosis – 6 %. Pathomorphosis in metastatic lymph nodes was observed in 22.7 % of cases.
Conclusion. The anti-tumor effect of polyoxidonium was confirmed on the basis of the induction of pathomorphosis of the tumor tissue of breast cancer.
About the Authors
M. M. Vasilyeva
Voronezh Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
4 Vaytsekhovskogo St., Voronezh 394036
I. P. Moshurov
Voronezh Regional Clinical Oncology Dispensary
Russian Federation
Competing Interests:
Russian Federation
4 Vaytsekhovskogo St., Voronezh 394036
Competing Interests:
L. Yu. Grivtsova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
N. N. Tupitsyn
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
N. A. Kozlov
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russi
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
M. B. Vasilyev
Voronezh Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
4 Vaytsekhovskogo St., Voronezh 394036
References
1. Aksel E.M. Situation with cancer care in Russia and CIS countries in 2008. Journal of N.N. Blokhin Russian Cancer Research Center 2010;2:9–51. (In Russ.).
2. Ivanova A.S., Puchkova N.G., Nekrasov A.V. et al. Mechanisms underlying adjuvant effects of polyoxidonium. Immunologiya gemopoeza = Haematopoiesis Immunology 2015;13(2):30–90. (In Russ.).
3. Dyakonova V.A., Pinegin B.V., Burakov V.V., Sharonov G.V. Cellular and molecular mechanisms of interaction between polyoxidonium and human immune cells. Immunologiya = Immunology 2004;25(3):145–52. (In Russ.).
4. Khaitov R.M., Pinegin B.V. Current concepts of the mechanisms of polyoxidonium action. Immunologiya = Immunology 2005;26(4):197. (In Russ.).
5. Pinegin B.V., Nekrasov A.V., Khaitov R.M. Immunomodulator polyoxidonium: mechanism of action and some aspects of its clinical use. Tsitokiny i vospaleniye = Cytokines and Inflammation 2004;3:41–7. (In Russ.).
6. Pinegin B.V. Polyoxidonium – a new generation of immunomodulators with a well-known structure and mechanism of action. Allergiya, astma i klinicheskaya immunologiya = Allergy, Asthma, and Clinical Immunology 2000;1:27–8. (In Russ.).
7. Fedenko A.A. Effect of some immunomodulators on the immune system and tolerability of adjuvant chemotherapy or radiotherapy in breast cancer patients. Summary of thesis … of candidate of medical sciences. Moscow, 2007. 181 p. (In Russ.).
8. Shamilov F.A., Elshina G.A., Burov D.A. et al. Effect of polyoxidonium on the subpopulations of intratumoral lymphocytes in patients with breast cancer. Immunologiya = Immunology 2013;4:207–11. (In Russ.).
9. Shamilov F.A. Changes in subpopulations of intratumoral lymphocytes during immunocorrecting therapy for breast cancer. Summary of thesis … of candidate of medical sciences. Moscow, 2014. 26 p. (In Russ.).
10. Grabovoy A.N., Tarasova T.A., Koshubarova M.V. Histological evaluation of tumor response to chemotherapy/radiotherapy. Eksperimentalnye issledovaniya, onkomorphologiya, onkoimmunologiya = Experimental studies, morphologic oncology, immunologic oncology 2012;6(2):38–143. (In Russ.).
Review
For citations:
Vasilyeva M.M., Moshurov I.P., Grivtsova L.Yu., Tupitsyn N.N., Kozlov N.A., Vasilyev M.B. Effect of immunoadjuvants on the disease course in patients with operable breast cancer. Tumors of female reproductive system. 2018;14(4):20-23. (In Russ.) https://doi.org/10.17650/1994-4098-2018-14-4-20-23
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