Email this article Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors
- Authors: Kedrova A.G.1,2, Lebedev D.P.1, Astakhov D.A.1, Kosyy V.V.1, Zabozlaev F.G.1,2, Ishchenko R.V.1
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Affiliations:
- Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation
- Academy of Postgraduate Education, Federal Research and Clinical Center, Federal Medical and Biological Agency
- Issue: Vol 14, No 4 (2018)
- Pages: 35-42
- Section: GYNECOLOGY. ORIGINAL REPORTS
- Published: 21.12.2018
- URL: https://ojrs.abvpress.ru/ojrs/article/view/617
- DOI: https://doi.org/10.17650/1994-4098-2018-14-4-35-42
- ID: 617
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Abstract
Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, to achieve reliable hemostasis, the patients should undergo embolization of vessels feeding the tumor. Good results have been achieved by selective catheterization of pelvic arteries using chemoembolization with HepaSphere microspheres (Biosphere Medical, France) delivering the therapeutic agent to the tumor. Hydrophilicity of microspheres loaded with cytostatics and their biological compatibility with tissues ensure long-term therapeutic effect by controlling tumor growth. Pronounced hemostatic and antitumor effects of this treatment method have been confirmed by a morphological study. This study analyzes 38 patients that underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan, which allowed surgery and further treatment.
About the authors
A. G. Kedrova
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation;Academy of Postgraduate Education, Federal Research and Clinical Center, Federal Medical and Biological Agency
Author for correspondence.
Email: kedrova.anna@gmail.com
ORCID iD: 0000-0003-1031-9376
Department of Obstetrics and Gynecology
28 Orekhovyy Boulevard, Moscow 115682,
91 Volokolamskoe Shosse, Moscow 125371
D. P. Lebedev
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation
28 Orekhovyy Boulevard, Moscow 115682
Russian FederationD. A. Astakhov
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation
28 Orekhovyy Boulevard, Moscow 115682
Russian FederationV. V. Kosyy
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation
28 Orekhovyy Boulevard, Moscow 115682
Russian FederationF. G. Zabozlaev
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation;Academy of Postgraduate Education, Federal Research and Clinical Center, Federal Medical and Biological Agency
Department of Clinical Laboratory Diagnostics and Pathological Anatomy
28 Orekhovyy Boulevard, Moscow 115682,
91 Volokolamskoe Shosse, Moscow 125371
R. V. Ishchenko
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation
28 Orekhovyy Boulevard, Moscow 115682
Russian FederationReferences
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