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Outcomes of combination therapy for stage IIA–IIIB cervical cancer

https://doi.org/10.17650/1994-4098-2018-14-4-50-55

Abstract

Objective: to analyze treatment outcomes in patients with stage IIA–IIIB cervical cancer.

Materials and methods. The study included 278 women with stage IIA–IIIB cervical cancer. Study participants were divided into 2 groups. Group 1 comprised 165 patients who received chemoradiotherapy + surgery (radical hysterectomy). Patients in group 2 received standard radiotherapy.

Results. Patients receiving combination therapy demonstrated better overall and relapse-free survival compared to those receiving standard treatment.

Conclusion. Both publications of other authors and our own results suggest high efficacy and safety of combination therapy for stage IIA–IIIB cervical cancer.

About the Authors

D. K. Reyes Santiago
Saint Petersburg Clinical Research Center for Specialized Medical Care (Oncology), Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation

68A Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, 2 Litovskaya St., Saint Petersburg 194100



A. S. Khadzhimba
Saint Petersburg Clinical Research Center for Specialized Medical Care (Oncology), Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation

68A Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, 2 Litovskaya St., Saint Petersburg 194100



I. V. Sobolev
Saint Petersburg Clinical Research Center for Specialized Medical Care (Oncology), Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation

68A Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, 2 Litovskaya St., Saint Petersburg 194100



A. A. Ilyin
Saint Petersburg Clinical Research Center for Specialized Medical Care (Oncology), Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation

68A Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, 2 Litovskaya St., Saint Petersburg 194100



S. Ya. Maksimov
Saint Petersburg Clinical Research Center for Specialized Medical Care (Oncology), Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Russian Federation

68A Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, 2 Litovskaya St., Saint Petersburg 194100



References

1. Ferlay J., Soerjomataram I., Ervik M. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):E359–86. PMID: 25220842. DOI: 10.1002/ijc.29210.

2. Davydov M.I., Aksel E.M. Malignant tumors in Russia and CIS countries in 2003. Moscow: Meditsinskoe informatsionnoe agentstvo, 2005. 268 p. (In Russ.).

3. Dolgushina V.F., Abramovskiy O.S. Prevalence of different types of human papillomavirus in patients with cervix disorders. Obstetrics and Gynecology 2011;4:69–74. (In Russ.).

4. Situation with cancer care in Russia in 2017. Ed. by A.D. Kaprin, V.V. Starinskiy, G.V. Petrova. Moscow: P. Herzen Moscow Oncology Research Institute – a branch of the National Medical Research Radiological Centre, Ministry of Health of Russia, 2018. 18 p. (In Russ.).

5. Malignant tumors in Russia in 2017 (incidence and mortality). Ed. by A.D. Kaprin, V.V. Starinskiy, G.V. Petrova. Moscow: P. Herzen Moscow Oncology Research Institute – a branch of the National Medical Research Radiological Centre, Ministry of Health of Russia, 2018. 13 p. (In Russ.).

6. Gong Lin M.D., Zhang Jia-Wen M.D., Yin Ru-Tie M.D. et al. Safety and efficacy of neoadjuvant chemotherapy followed by radical surgery versus radical surgery alone in locally advanced cervical cancer patient. Int J Gynecol Cancer 2016;26(4):722–8. PMID: 26905330. DOI: 10.1097/IGC.0000000000000658.

7. Park J.Y., Kim D.Y., Kim J.H. et al. Comparison of outcomes between radical hysterectomy followed by tailored adjuvant therapy versus primary chemoradiation therapy in IB2 and IIA2 cervical cancer. J Gynecol Oncol 2012;23(4):226–34. PMID: 23094125. DOI: 10.3802/jgo.2012.23.4.226.

8. Katsumata N., Yoshikawa H., Kobayashi H. et al. Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102). Br J Cancer 2013;108(4):1957–63. PMID: 23640393. DOI: 10.1038/bjc.2013.179.

9. Jeong-Yeol P., Dae-Yeon K., Jong-Hyeok K. et al. Comparison of outcomes between radical hysterectomy followed by tailored adjuvant therapy versus primary chemoradiation therapy in IB2 and IIA2 cervical cancer. J Gynecol Onco. 2012;23(4):226–34. PMID: 23094125. DOI: 10.3802/jgo.2012.23.4.226.

10. Sun H., Xin J., Lu Z. et al. Potential molecular mechanisms for improved prognosis and outcome with neoadjuvant chemotherapy prior to laparoscopical radical hysterectomy for patients with cervical cancer. Cell Physiol Biochem 2013;32(5):1528–40. PMID: 24335178. DOI: 10.1159/000356590.

11. Landoni F., Sartori E., Maggino T. et al. Is there a role for postoperative treatment in patients with stage Ib2–IIb cervical cancer treated with neo-adjuvant chemotherapy and radical surgery? An Italian multicenter retrospective study. Gynecol Oncol 2014;132(3):611–7. DOI: 10.1016/j.ygyno.2013.12.010.

12. Morice P., Rouanet P., Rey A. et al. Results of the GYNECO 02 study, an FNCLCC phase III trial comparing hysterectomy with no hysterectomy in patients with a (clinical and radiological) complete response after chemoradiation therapy for stage IB2 or II cervical cancer. Oncologist 2012;17(1):64–71. PMID: 22234626. DOI: 10.1634/theoncologist.2011-0276.

13. Peters W.A., Liu P.Y., Barrett R.J. et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk earlystage cancer of the cervix. J Clin Oncol. 2000;18(8):1606–13. PMID: 10764420. DOI: 10.1200/JCO.2000.18.8.1606.

14. Ferrandina G., Palluzzi E., Gallotta V. et al. Neo-adjuvant platinum-based chemotherapy followed by chemoradiation and radical surgery in locally advanced cervical cancer (Lacc) patients: A phase II study. Eur J Surg Oncol. 2018 Jul;44(7):1062–8. PMID: 29753611. DOI: 10.1016/j.ejso.2018.04.019.


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For citations:


Reyes Santiago D.K., Khadzhimba A.S., Sobolev I.V., Ilyin A.A., Maksimov S.Ya. Outcomes of combination therapy for stage IIA–IIIB cervical cancer. Tumors of female reproductive system. 2018;14(4):50-55. (In Russ.) https://doi.org/10.17650/1994-4098-2018-14-4-50-55

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)