Clinical and morphological characteristics of ovarian neuroendocrine tumors
https://doi.org/10.17650/1994-4098-2019-15-1-58-66
Abstract
This article describes the clinical and epidemiological characteristics of neuroendocrine tumors (NET) of the female reproductive system, including ovarian NET. We focus on current approaches to the classification of these tumors based on the embryogenesis and biological properties of the tumor. We also cover the most important clinical and morphological characteristics of ovarian NET as well as their microscopic and immunohistochemical features.
About the Authors
S. O. Nikogosyan
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
M. N. Sekerskaya
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
T. S. Tagibova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
O. A. Anurova
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
24 Kashirskoe Shosse, Moscow 115478
References
1. Oberndorfer S. Karzinoide Tumoren des Dunndarms. Frankf Z Pathol 1907;1:425– 32.
2. Williams E.D., Sandler M. The classification of carcinoid tumours. Lancet 1963;1:238–9. PMID: 14000847.
3. Solcia E., Klöppel G., Sobin L. et al. Histological typing of endocrine tumours. 2nd edn. World Health Organization. Berlin: Springer, 2000.
4. Klöppel G., Perren A., Heitz P.U. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann NY Acad Sci 2004;1014:13–27. DOI: 10.1196/annals.1294.002.
5. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer 2011;18(suppl 1):S1–16. DOI: 10.1530/ERC-11-0013.
6. Schmitt A.M., Blank A., Marinoni I. et al. Histopathology of NET: current concepts and new developments. Best Pract Res Clin Endocrinol Metab 2016;30(1):33–43. PMID: 26971842. DOI: 10.1016/j.beem.2016.02.002.
7. Bosman F., Carneiro F., Hruban R.H., Theise N.D. WHO classification of Tumours of the digestive system. 4th edn. Lyon: IARC Press, 2010.
8. Rindi G., Kloppel G., Alhman H. et al. TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 2006;449(4):395–401. PMID: 16967267. DOI: 10.1007/s00428-006-0250-1.
9. Rindi G., Kloppel G., Couvelard A. et al. TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch 2007;451(4):757–62. PMID: 17674042. DOI: 10.1007/s00428-0070452-1.
10. Kurman R.J., Carcangiu M.L., Herrington C.S., Young R.H. WHO classification of tumours of the female reproductive organs. Lyon: IARC Press, 2014.
11. Tavassoli F.A., Devilee P. Pathology and genetics of tumors of the breast and female genital organs. Lyon: IARC Press, 2003.
12. Rouzbahman M., Clarke B. Neuroendocrine tumors of the gynecologic tract: Select topics. Semin Diagn Pathol 2013;30:224–33.
13. Robboy S.J., Norris H.J., Scully R.E. Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. Cancer 1975;36(2):404–18. PMID: 1157010.
14. Soga J., Osaka M., Yakuwa Y. Carcinoids of the ovary: an analysis of 329 reported cases. J Exp Clin Cancer Res 2000;19(3):271–80. PMID: 11144518.
15. Díaz-Montes T.P., Rosenthal L.E., Bristow R.E., Grumbine F.C. Primary insular carcinoid of the ovary. Gynecol Oncol. 2006;101(1):175–8. PMID: 16298421. DOI: 10.1016/j.ygyno.2005.10.015.
16. Lagoudianakis E.E., Markogiannakis H., Karantzikos G. et al. Primary insular carcinoid of the ovary. Eur J Gynaecol Oncol 2008;29(5):554–5. PMID: 19051836.
17. Robboy’s Pathology of the Female Reproductive Tract. 2nd edn. Eds.: S.J. Robboy et al. London: Churchill Livingstone, 2009.
18. Kurabayashi T., Minamikawa T., Nishijima S. et al. Primary strumal carcinoid tumor of the ovary with multiple bone and breast metastases. J Obstet Gynaecol Res 2010;36(3):567–71. PMID: 20598039. DOI: 10.1111/j.1447-0756.2010.01231.x.
19. Baker P.M., Oliva E., Young R.H. et al. Ovarian mucinous carcinoids including some with a carcinomatous component: a report of 17 cases. Am J Surg Pathol 2001;25:557–68.
20. Buis C.C., van Doorn H.C., Dinjens W.N., Ewing P.C. Mucinous carcinoid of the ovary: report of a case with metastasis in the contralateral ovary after ten years. Rare Tumors 2010;2(3):e39. PMID: 21139955. DOI: 10.4081/rt.2010.e39.
21. Wolpert H.R., Fuller A.F., Bell D.A. Primary mucinous carcinoid tumor of the ovary. A case report. Int J Gynecol Pathol 1989;8:156–62. PMID: 2541091.
22. Young R.H., Oliva E., Scully R.E. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol 1994;18:1102–16.
23. Matias-Guiu X., Prat J., Young R.H. et al. Human parathyroid hormone-related protein in ovarian small cell carcinoma. An immunohistochemical study. Cancer 1994;73(7):1878–81. PMID: 8137214.
24. McCluggage W.G., Oliva E., Connolly L.E. et al. An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. Int J Gynecol Pathol 2004;23:330–6. PMID: 15381902.
25. Aguirre P., Thor A.D., Scully R.E. Ovarian small cell carcinoma. Histogenetic considerations based on immunohistochemical and other findings. Am J Clin Pathol 1989;92:140–9.
26. Witkowski L., Carrot-Zhang J., Albrecht S. et al. Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. Nat Genet 2014;46:438–43.
27. Jelinic P., Mueller J.J., Olvera N. et al. Recurrent SMARCA4 mutations in small cell carcinoma of the ovary. Nat Genet 2014;46:424–6.
28. Ramos P., Karnezis A.N., Craig D.W. et al. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat Genet 2014;46:427–9.
29. Foulkes W.D., Clarke B.A., Hasselblatt M. et al. No small surprise – small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour. J Pathol 2014;233(3):209–14. PMID: 24752781. DOI: 10.1002/path.4362.
30. Eichhorn J.H., Young R.H., Scully R.E. Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic, and flow cytometric analysis of 11 cases. Am J Surg Pathol 1992;16(10):926–38. PMID: 1384368.
31. Veras E., Deavers M.T., Silva E.G., Malpica A. Ovarian nonsmall cell neuroendocrine carcinoma: A clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol 2007;31(5):774–82. PMID: 17460463. DOI: 10.1097/01.pas.0000213422.53750.d1.
32. Chen K.T. Composite large-cell neuroendocrine carcinoma and surface epithelialstromal neoplasm of the ovary. Int J Surg Pathol 2000;8(2):169–74. PMID: 11493984. DOI: 10.1177/106689690000800214.
33. Modlin I.M., Lye K.D., Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003;97(4):934–59. PMID: 12569593. DOI: 10.1002/cncr.11105.
34. Tan E.H., Tan C. Imaging of gastroenteropancreatic neuroendocrine tumors. J Clin Oncol 2011;2(1):28. PMID: 21603312. DOI: 10.5306/wjco.v2.i1.28.
35. Handbook of Neuroendocrine Tumors. Ed. by M. Caplin, L. Kvols. Moscow: Prakticheskaya meditsina, 2011. Pp. 11, 17–19, 23, 37, 43, 54, 88, 100. (In Russ.).
Review
For citations:
Nikogosyan S.O., Sekerskaya M.N., Tagibova T.S., Anurova O.A. Clinical and morphological characteristics of ovarian neuroendocrine tumors. Tumors of female reproductive system. 2019;15(1):58-66. (In Russ.) https://doi.org/10.17650/1994-4098-2019-15-1-58-66
Views:
967
Email this article 