Preview

Tumors of female reproductive system

Advanced search

Phyllodes breast tumor. From diagnostic to pathomorphological examination

https://doi.org/10.17650/1994-4098-2021-17-3-69-78

Abstract

Background. Phylloid tumors are a fairly rare pathology (about 0.3–0.5 % of all breast tumors), which is why there is no single protocol for the treatment of this pathology. Also, due to the lack of data and the rare occurrence, it is difficult to diagnose and choose the final management tactics of the patient. Phylloid tumors can be benign, borderline, and malignant neoplasms, which also complicates the treatment process. The final decision on the choice of patient management tactics can be made only after receiving the results of a planned pathomorphological examination.

Materials and methods. In this article, we will discuss the results of major retrospective studies, including data on epidemiology, etiology, diagnostic approach, strategies and results of treatment of phylloid breast tumors, as well as present data on patients treated at the Russian Scientific Center of Radiology of the Ministry of Health of the Russian Federation for the period from January 2010 to February 2021.

Results. The main methods of instrumental diagnosis of phylloid tumors are mammography, ultrasound and MRI. Morphological examination is important in making a diagnosis. Fine-needle biopsy often does not allow establishing an accurate diagnosis, and therefore the main method of diagnosis remains pathohistological examination. The main method of treatment of phylloid tumors remains surgical, where, depending on the trepan biopsy, the question of the feasibility of performing an organ-preserving operation is decided.

Conclusion. Phylloid tumors are a rare type of breast neoplasm, which is the reason for the relatively small amount of scientific research that addresses this particular problem.

About the Authors

V. A. Solodkiy
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



O. S. Khodorovich
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



A. A. Kalinina-Masri
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



K. D. Sarkisyan
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



T. V. Sherstneva
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



V. O. Kleshneva
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



L. B. Kanakhina
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



I. A. Lazukina
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



K. K. Letts-Orletsov
Russian Scientific Center of Radiology and Nuclear Medicine at the Ministry of Health of Russia
Russian Federation

86 Profsoyuznaya St., Moscow 117997



References

1. Zikiryakhodzhaev A.D., Shirokikh I.M., Kharchenko N.V. et al. Phyloid tumors of the mammary glands. Current state of the problem. Issledovaniya i praktika v medicine = Research and Practice in Medicine 2017;4(2):13–22. (In Russ.).

2. Solodkiy V.A., Khodorovich O.S., Sarkisyan K.D., Kalinina-Masri A.A. Symmetrizing interventions in organ-preserving and reconstructive operations in patients with breast cancer. Vestnik Rossijskogo nauchnogo centra rentgenoradiologii Minzdrava Rossii = Bulletin of the Russian Scientific Center for Roentgenoradiology of the Ministry of Health of Russia 2019;19(2):52–63. (In Russ.).

3. Khodorovich O.S., Kalinina-Masri A.A., Kanakhina L.B. et al. Reconstructive plastic surgery using expander/implant and radiation therapy for breast cancer. Bulletin of the Russian Scientific Center for Radiology 2020;20(1):1–14. (In Russ.).

4. Bansal A., Kaur M., Dalal V. Pleomorphic sarcoma of breast: a report of two cases and review of literature. Acta Med Iran 2017;55(4):272–6.

5. Textbook of Uncommon Cancer, 5th edn. Eds.: Raghavan D., Ahluwalia M.S., Blanke C.D. Wiley-Blackwell, 2017. 1296 p.

6. Gervais M.K., Burtenshaw S.M., Maxwell J. et al. Clinical outcomes in breast angiosarcoma patients: A rare tumor with unique challenges. J Surg Oncol 2017;116(8)1056–61.

7. Petrovskiy V.Yu., Trotsenko S.D., Sherstneva T.V. A clinical case of pleomorphic sarcoma of the mammary glands. Vestnik RNTSRR = Bulletin of the RNTSRR 2020;(20). Available at: http:// vestnik.rncrr.ru/vestnik/v20/docs/ petrovskiy_t4.pdf. (In Russ.).

8. Wiratkapun C., Piyapan P., Lertsithichai P., Larbcharoensub N. Fibroadenoma versus phyllodes tumor: distinguishing factors in patients diagnosed with fibroepithelial lesions after a core needle biopsy. Diagn Interv Radiol 2014;20(1):27–33. DOI: 10.5152/dir.2013.131333.

9. Jang J.H., Choi M.Y., Lee S.K. et al. Clinicopathologic risk factors for the local recurrence of phyllodes tumors of the breast. Ann Surg Oncol 19(8):2612–7. DOI: 10.1245/s10434-012-2307-5.


Review

For citations:


Solodkiy V.A., Khodorovich O.S., Kalinina-Masri A.A., Sarkisyan K.D., Sherstneva T.V., Kleshneva V.O., Kanakhina L.B., Lazukina I.A., Letts-Orletsov K.K. Phyllodes breast tumor. From diagnostic to pathomorphological examination. Tumors of female reproductive system. 2021;17(3):69-78. (In Russ.) https://doi.org/10.17650/1994-4098-2021-17-3-69-78

Views: 9681


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)