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Heterogeneity of EpCAM-positive cells in low-grade serous ovarian carcinoma ascitic fluid: a clinical case
- Authors: Kaigorodova E.V.1,2, Kovalev O.V.2, Chernyshova A.L.1, Vtorushin S.V.1,2, Shpileva .V.1
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Affiliations:
- Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Siberian State Medical University
- Issue: Vol 17, No 4 (2021)
- Pages: 90-95
- Section: GYNECOLOGY. CLINICAL CASE
- Published: 20.12.2021
- URL: https://ojrs.abvpress.ru/ojrs/article/view/890
- DOI: https://doi.org/10.17650/1994-4098-2021-17-4-90-95
- ID: 890
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Abstract
Ovarian cancer is one of the most malignant and aggressive tumors of the female reproductive system. Late diagnosis is one of the most significant problems: more than two-thirds of cases are detected only at stage III–IV. Ovarian cancer is characterized by a unique metastatic process. Implantation is the earliest and most common way of metastasis. It is often accompanied by fluid accumulation in the abdominal cavity, known as ascites. We report a case of low-grade serous ovarian carcinoma with a large heterogeneity of tumor cells in the ascitic fluid detected using multicolor flow cytometry. We demonstrated the advantages and benefits of this method in the diagnosis of ovarian cancer. Multicolor flow cytometry opens new horizons for liquid biopsy in oncology.
About the authors
E. V. Kaigorodova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Author for correspondence.
Email: zlobinae@mail.ru
ORCID iD: 0000-0003-4378-6915
Evgeniya Viktorovna Kaigorodova.
5, Kooperativnyy St., Tomsk 634009; 2, Mosсovskiy Trakt, Tomsk 634050.
Russian FederationO. V. Kovalev
Siberian State Medical University
ORCID iD: 0000-0002-6826-725X
2, Mosсovskiy Trakt, Tomsk 634050.
Russian FederationA. L. Chernyshova
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
ORCID iD: 0000-0002-8194-2811
5, Kooperativnyy St., Tomsk 634009.
Russian FederationS. V. Vtorushin
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
ORCID iD: 0000-0002-1195-4008
5, Kooperativnyy St., Tomsk 634009; 2, Mosсovskiy Trakt, Tomsk 634050.
Russian FederationO. V. Shpileva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
ORCID iD: 0000-0003-0617-4688
5, Kooperativnyy St., Tomsk 634009.
Russian FederationReferences
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