Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer

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Abstract

Mass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the proportion of extracellular and membrane proteins constituted 13 %. After using some selection criteria to analyze the findings, the authors present a list of 31 potential biomarkers and describe 12 promising breast anticancer therapeutic targets.

About the authors

V. E. Shevchenko

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

M. A. Taipov

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Author for correspondence.
Email: martaip@rambler.ru
Russian Federation

S. V. Kovalev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

N. E. Arnotskaya

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

O. M. Pavlova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

I. A. Kudryavtsev

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

Z. N. Nikiforova

N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow

Russian Federation

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