Assessment of reproductive outcomes and quality of life in patients after radical trachelectomy
- Authors: Chernyshova A.L.1, Kolomiets L.A.1,2, Trushchuk Y.M.1, Dil O.S.1, Chernov V.I.1,3, Marchenko E.S.4, Chekalkin T.L.4, Antipov V.A.5, Krasilnikov S.E.6
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Affiliations:
- Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of Russia
- Tomsk National Research Polytechnic University
- Research Institute of Medical Materials and Implants with Shape Memory
- City Clinical Hospital No. 24, Moscow Healthcare Department
- E.N. Meshalkin. National Medical Research Center, Ministry of Health of Russia
- Issue: Vol 18, No 2 (2022)
- Pages: 77-85
- Section: GYNECOLOGY. ORIGINAL REPORTS
- Published: 16.09.2022
- URL: https://ojrs.abvpress.ru/ojrs/article/view/973
- DOI: https://doi.org/10.17650/1994-4098-2022-18-2-77-85
- ID: 973
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Full Text
Abstract
Cervical cancer occupies a leading position in the structure of oncogynecological pathology. Radical trachelectomy (RT) has entered the standards of treatment of invasive cervical cancer in patients of reproductive age. RT can be performed by transabdominal and laparoscopic approaches. The purpose of our study was a comparative assessment of the effectiveness and study of the quality of life in patients after RT. In total, 99 surgical interventions were performed using technologies developed at Oncology Research Institute, Tomsk National Research Medical Center of Russian Academy of Sciences. The features and results of treatment are described, including oncological efficacy, reproductive results (reproductive potential, peculiarities of the course of pregnancies and childbirth). The analysis of the study of the quality of life of patients after RT according to the criteria of modern questionnaires EORTC QlQC30 and QLQ-CX24.
About the authors
A. L. Chernyshova
Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: alacher@list.ru
ORCID iD: 0000-0002-8194-2811
5 Kooperativnyy Pereulok, Tomsk 634009
Russian FederationL. A. Kolomiets
Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences;Siberian State Medical University, Ministry of Health of Russia
Email: info@abvpress.ru
ORCID iD: 0000-0002-6854-8940
5 Kooperativnyy Pereulok, Tomsk 634009;
2 Moskovskiy Trakt, Tomsk 634050
Russian FederationYu. M. Trushchuk
Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: info@abvpress.ru
5 Kooperativnyy Pereulok, Tomsk 634009
Russian FederationO. S. Dil
Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: info@abvpress.ru
5 Kooperativnyy Pereulok, Tomsk 634009
Russian FederationV. I. Chernov
Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences;Tomsk National Research Polytechnic University
Email: info@abvpress.ru
ORCID iD: 0000-0002-5524-9546
5 Kooperativnyy Pereulok, Tomsk 634009;
30 Prospekt Lenina, Tomsk 634050
Russian FederationE. S. Marchenko
Research Institute of Medical Materials and Implants with Shape Memory
Email: info@abvpress.ru
ORCID iD: 0000-0003-4615-5270
1719-oy Gvardeyskoy Divizii St., Tomsk 634045
Russian FederationT. L. Chekalkin
Research Institute of Medical Materials and Implants with Shape Memory
Email: info@abvpress.ru
1719-oy Gvardeyskoy Divizii St., Tomsk 634045
Russian FederationV. A. Antipov
City Clinical Hospital No. 24, Moscow Healthcare Department
Email: info@abvpress.ru
10 Pistsovaya St., Moscow 127015
Russian FederationS. E. Krasilnikov
E.N. Meshalkin. National Medical Research Center, Ministry of Health of Russia
Author for correspondence.
Email: info@abvpress.ru
ORCID iD: 0000-0003-0687-0894
15 Rechkunovskaya St., Novosibirsk 630055
Russian FederationReferences
- Okugawa K., Kobayashi H., Sonoda K. et al. Oncologic and obstetric outcomes and complications during pregnancy after fertility-sparing abdominal trachelectomy for cervical cancer: A retrospective review. Int J Clin Oncol 2017;22(2):340–346. doi: 10.1007/s10147-016-1059-9.
- Yunusova N.V., Spirina L.V., Chernyshova A.L. et al. Cell motility proteins in endometrium carcinoma and endometrial hyperplasia: association with cancer risk. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2020;19(5):51–60. (In Russ.). doi: 10.21294/1814-4861-2020-19-5-51-60.
- Salvo G., Pareja R., Ramirez P.T. Minimally invasive radical trachelectomy: Considerations on surgical approach. Best Pract Res Clin Obstet Gynaecol 2021;20:S1521-6934(21)00018-3. doi: 10.1016/j.bpobgyn.2021.01.009.
- Smith J.R., Boyle D.C., Corless D.J. et al. Abdominal radical trachelectomy: a new surgical technique for the conservative management of cervical carcinoma. Br J Obstet Gynaecol 1997.
- Nezhat C., Roman R.A., Rambhatla A., Nezhat F. Reproductive and oncologic outcomes after fertility-sparing surgery for early stage cervical cancer: a systematic review. Fertil Steril 2020;113(4):685–703. doi: 10.1016/j.fertnstert.2020.02.003.
- Kondakova I.V., Spirina L.V., Koval V.D. et al. Chymotripsin-like activity and subunit composition of proteasomes in human cancers. Molekuliarnaya Biologiya 2014;48(3):444–51. doi: 10.7868/s0026898414030112.
- Salvo G., Ramirez P.T., Leitao M. et al. International radical trachelectomy assessment: IRTA study. Int J Gynecol Cancer 2019;29(3):635–8. doi: 10.1136/ijgc-2019-000273.
- Nitecki R., Woodard T., Rauh-Hain J.A.. Fertility-sparing treatment for early-stage cervical, ovarian, and endometrial malignancies. Obstet Gynecol 2020;136(6):1157–69. doi: 10.1097/AOG.0000000000004163.
- Spirina L.V., Kondakova I.V., Usynin E.A. et al. Proteasome activity and the content of growth factors in kidney, bladder and endometrial cancer. Rossijskiy onkologicheskiy zhurnal = Russian Journal of Oncology 2010;(1): 23–5. (In Russ.).
- Nemejcova K., Kocian R., Kohler C. et al. Central pathology review in SENTIX, a prospective observational international study on sentinel lymph node biopsy in patients with early-stage cervical cancer (ENGOT-CX2). Cancers (Basel) 2020; 12(5):1115. DOI: 10.3390/ cancers12051115.
- Chernyshova А., Kolomiets L., Chekalkin T. et al. Fertility-sparing surgery using knitted tini mesh implants and sentinel lymph nodes: A 10-year experience. J Invest Surg 2021;34:1110–8. doi: 10.1080/08941939.2020.1745965
- Chernyshova A.L., Kolomiets L.A., Gunter V.E., Marchenko E.S. New surgical aspects of organpreserving treatment in patients with invasive cervical cancer after radical trachelectomy. Voprosy onkologii = Questions of Oncology 2017;63(5):743–7. (In Russ.).
- Choi Y.J., Moskowitz J.M., Myung S.K. et al. Cellular phone use and risk of tumors: systematic review and metaanalysis. Int J Environ Res Public Health 2020;17:8079.
- Lu R., Zhao X., Li J. et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020;395(10224):565–74. doi: 10.1016/S0140-6736(20)30251-8.
- McCormack M., Gaffney D., Tan D. et al. The Cervical Cancer Research Network (Gynecologic Cancer InterGroup) roadmap to expand research in lowand middle-income countries. Int J Gynecol Cancer 2021;31(5):775–8. doi: 10.1136/ijgc-2021-002422.
- Spirina L.V., Kondakova I.V., Kolomiets L.A. et al. Proteasome activity and their subunit composition in hyperplastic processes and endometrial cancer. Opukholi zhenskoy reproduktivnoy systemy = Tumors of the female reproductive system 2011;(4):64–8. (In Russ.).
- Small W., Peltecu G., Puiu A. et al. Cervical cancer in Eastern Europe: review and proceedings from the cervical cancer research conference. Int J Gynecol Cancer 2020. doi: 10.1136/ijgc-2020-001652.
- Guani B., Dorez M., Magaud L. et al. Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL trial. Int J Gynecol Cancer 2019;29:447–52. doi: 10.1136/ijgc-2018-000089.
- Lecuru F.R., McCormack M., Hillemanns P. et al. SENTICOL III: an international validation study of sentinel node biopsy in early cervical cancer. A GINECO, ENGOT, GCIG and multicenter study. Int J Gynecol Cancer 2019;29:829–34. doi: 10.1136/ijgc-2019-000332.
- Bochkareva N.V., Kolomiets L.A., Chernyshova A.L. Do patients with hyperplastic processes and endometrial cancer need rehabilitation against the background of metabolic syndrome? Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2010;(5):71–7. (In Russ.).
- National Comprehensive Cancer Network (NCCN). Clinical Practice Guidelines in Oncology. Cervical Cancer. Version 1.2020, 2020.
- Arbyn M., Weiderpass E., Bruni L. et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health 2020;8:e191–203. doi: 10.1016/S2214-109X(19)30482-6.
- Yunusova N.V., Kondakova I.V., Kolomiets L.A. et al. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia-Pacific J Clin Oncol 2018;14(3):134–40. doi: 10.1111/ajco.12780.
- Spirina L.V., Bochkareva N.V., Kondakova I.V. et al. Regulation of insulin-like growth factors and NF-kappaB by proteasome system in endometrial cancer. Molekuliarnaya Biologiya 2012;46(3):452–60.
- Chernyshova A.L., Kolomiets L.A., Sinilkin I.G. et al. Optimization of approaches to choosing the scope of surgical treatment in patients with cervical cancer (the role of sentinel lymph node research). Voprosy onkologii = Questions of Oncology 2016;62(6):807– 11. (In Russ.).
- Segarra-Vidal B., Persson J., Falconer H. Radical trachelectomy. Int J Gynecol Cancer 2021;31(7):1068–74. doi: 10.1136/ijgc-2020-001782.
- Chernyshova A.L., Kolomiets L.A., Bochkareva N.V., Kritskaya N.G. Immunohistochemical prognostic criteria for endometrial cancer. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2010;(1):79–84. (In Russ.).
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