Email this article Proteasome activity and subunit composition in endometrial hyperplasia and cancer
- Authors: Spirina L.V.1, Kondakova I.V.1, Kolomiets L.A.1, Chernysova A.L.1, Asadchikova O.N.1, Sharova N.P.2, Koval V.D.1
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Affiliations:
- Cancer Research Institute, Tomsk Scientific Centre, SB RAMS
- N.K. Koltzov Institute of Developmental Biology RAS, Moscow
- Issue: No 4 (2011)
- Pages: 64-67
- Section: GYNECOLOGY. PROBLEM
- Published: 18.11.2011
- URL: https://ojrs.abvpress.ru/ojrs/article/view/200
- DOI: https://doi.org/10.17650/1994-4098-2011-0-4-64-67
- ID: 200
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Abstract
In endometrial hyperplasia the total proteasome activity was not changed however the 26S proteasome activity was increased in comparison with the normal tissues. In endometrial cancer the high total proteasome activity and activities of 26S and 20S proteasomes wer e revealed. The changes in proteasome activities were correlated with the decreased content of α1α2α3α5α6α7 proteasome subunits and increased con- tents of LMP2, LMP7 and PA28β proteasome subunits compared to that in nonaltered tissues. Low content of α1α2α3α5α6α7 proteasome subunits was revealed at the second stage of cancer patients in comparison with that at the first stage.
About the authors
L. V. Spirina
Cancer Research Institute, Tomsk Scientific Centre, SB RAMS
Author for correspondence.
Email: SpirinaLV@oncology.tomsk.ru
Russian Federation
I. V. Kondakova
Cancer Research Institute, Tomsk Scientific Centre, SB RAMSRussian Federation
L. A. Kolomiets
Cancer Research Institute, Tomsk Scientific Centre, SB RAMSRussian Federation
A. L. Chernysova
Cancer Research Institute, Tomsk Scientific Centre, SB RAMSRussian Federation
O. N. Asadchikova
Cancer Research Institute, Tomsk Scientific Centre, SB RAMSRussian Federation
N. P. Sharova
N.K. Koltzov Institute of Developmental Biology RAS, MoscowRussian Federation
V. D. Koval
Cancer Research Institute, Tomsk Scientific Centre, SB RAMSRussian Federation
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