Preview

Tumors of female reproductive system

Advanced search

Breast conserving surgery in the treatment of breast cancer stage III

https://doi.org/10.17650/1994-4098-2016-12-1-52-55

Abstract

This study evaluated the ability to perform organ-operation in breast cancer stage III. Highlight 2 similar groups of patients, depending on the extent of the procedure: in the 1st (main) were performed breast conserving surgery (BCS), in the 2nd (control) radical mastectomy (RM) with preservation of the pectoral muscles. It was analyzed overall survival (OS), disease-free survival (DFS); the frequency of postoperative complications and aesthetic results of the treatment. The 3-, 5- and 10-year OS group did not differ significantly and amounted to 80.0 ± 8.0, 87.0 ± 4.6 %; 70.2 ± 9.7, 67.8 ± 6.7 %; 61.4 ± 11.8, 62.2 ± 7.2 %, respectively (p > 0.05). The 3-, 5- and 10-year DFS group did not differ significantly and amounted to 68.1 ± 9.2, 80.7 ± 5.5 %; 58.9 ± 10.9, 67.2 ± 6.6 %; 58.9 ± 10.9, 60.3 ± 7.2 %), respectively (p > 0.05). The frequency of postoperative complications was in the group of BCS 7.7 %, in the group of RM – 6.9 % (p > 0.05). The aesthetic results of the treatment: satisfactory when BCS, unsatisfactory at RM.

About the Authors

D. V. Khaylenko
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1 Ostrovityanova St., Moscow, 117997, Russia
Russian Federation


S. M. Portnoy
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Russian Federation


Yu. S. Egorov
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Russian Federation


V. A. Khaylenko
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1 Ostrovityanova St., Moscow, 117997, Russia N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia
Russian Federation


References

1. Давыдов М.И., Аксель Е.М. Злокачественные новообразования в России и странах СНГ в 2003 году. М.: МИА, 2005. С. 268. [Davydov М.I., Аksel’ Е.М. Malignant tumors in Russia and CIS countries in 2003. Мoscow: МIА, 2005. P. 268. (In Russ.)].

2. Каприн А.Д., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2013 году. М., 2014. С. 26–8; 116. [Kaprin А.D., Starinskiy V.V., Petrovа G.V. Status of the oncologic assistance to the population of Russia in 2013. Мoscow, 2014. Pp. 26–8; 116. (In Russ.)].

3. Mitov F.S., Molov V.V. Breast-conserving surgery in early-stage breast cancer (indications, local recurrences, survival, cosmetic results). Folia Med (Plovdiv) 2006;48(1):23–30.

4. Семиглазов В.Ф., Палтуев Р.М., Семиглазова Т.Ю. и др. Клинические рекомендации по диагностике и лечению рака молочной железы. М.: АБВ-пресс, 2013. С. 86–8; 101–2; 151–60; 234. [Semiglazov V.F., Paltuev R.М., Semiglazovа Т.Yu. et al. Clinical recommendations on the diagnostics and treatment of the mammary gland cancer. Мoscow: АBV-press, 2013. Pp. 86–8; 101–2; 151–60; 234. (In Russ.)].

5. Cho J.H., Park J.M., Park H.S. et al. Oncologic safety of breast-conserving surgery compared to mastectomy in patients receiving neoadjuvant chemotherapy for locally advanced breast cancer. J Surg Oncol 2013;108(8): 531–6.

6. Hudis C., Modis S. Preoperative chemotherapy for breast cancer: miracle or mirage? JAMA 2007;298(22):2665–7.

7. Mittendorf E.A., Buchholz T.A., Tucker S.L. et al. Impact of chemotherapy sequencing on local-regional failure risk in breast cancer patients undergoing breast-conserving therapy. Ann Surg 2013;257(2):173–9.

8. Murhny С. Neoadjuvant therapy for breast cancer. Oncology 2009;23(Suppl):20–7.

9. Onitilo A.A., Engel J.M., Stankowski R.V., Doi S.A. Survival comparisons for breast conserving surgery and mastectomy revisited: community experience and the role of radiation therapy. Clin Med Res 2015;13(2):65–73.

10. Shin H.C., Han W., Moon H.G. et al. Breast-conserving surgery after tumor downstaging by neoadjuvant chemotherapy is oncologically safe for stage III breast cancer patients. Ann Surg Oncol 2013;20(8):2582–9.

11. Демидов В.П., Пак Д.Д. Органосохраняющие операции в лечении локализованного и местно-распространенного рака молочной железы. Маммология 1993;(4):45–51. [Demidov V.P., Pak D.D. Оrgan preserving operations in the treatment of the localized and locally spread mammary gland cancer. Mammologiya = Маmmology 1993;(4):45–51. (In Russ.)].

12. Демидов В.П., Островцев Л.Д. Функционально-щадящая мастэктомия в лечении местно-распространенного рака молочной железы IIB и IIIB (Т1–3N1–2М0) стадий. Маммология 1993;(3):54–61. [Demidov V.P., Оstrovtsev L.D. Function preserving mastectomy in the treatment of the locally spread IIB and IIIB mammary gland cancers (Т1–3N1–2М0). Mammologiya = Маmmology 1993;(3):54–61. (In Russ.)].

13. DeVita V.T., Lawrence T.S., Rosenberg S.A. Cancer: principles & practice of oncology. 8th ed. Philadelphia: Lippincott, 2008. Pp. 1624–5.

14. Портной С.М. Лечение местно-распространенного рака молочной железы. Актуальные аспекты клинической маммологии. Под ред. Е.Б. Камповой-Полевой, С.М. Портного. М.: Авторская академия, 2014. С. 244; 263–5. [Portnoy S.М. Treatment of the locally spread mammary gland cancer. Аctual aspects of the clinical mammology. Ed. by Е.B. Kampova-Polevaya, S.М. Portnoy. Мoscow: Аvtorskaya Academiya, 2014. Pp. 244; 263–5. (In Russ.)].

15. Rutgers E.J. Quality control in the locoregional treatment of breast cancer. Eur J Cancer 2001;37(4):447–53.


Review

For citations:


Khaylenko D.V., Portnoy S.M., Egorov Yu.S., Khaylenko V.A. Breast conserving surgery in the treatment of breast cancer stage III. Tumors of female reproductive system. 2016;12(1):52-55. (In Russ.) https://doi.org/10.17650/1994-4098-2016-12-1-52-55

Views: 838


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)