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Опухоли женской репродуктивной системы

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ПАЛБОЦИКЛИБ В КОМБИНАЦИИ С ГОРМОНОТЕРАПИЕЙ ПРИ ЛЮМИНАЛЬНОМ HER2-НЕГАТИВНОМ МЕТАСТАТИЧЕСКОМ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ: НОВАЯ ВЫСОКОЭФФЕКТИВНАЯ СТРАТЕГИЯ ЛЕКАРСТВЕННОГО ЛЕЧЕНИЯ

https://doi.org/10.17650/1994-4098-2017-13-3-28-40

Аннотация

Обзор посвящен новому пероральному таргетному препарату палбоциклибу и его месту в терапии люминального (эстроген-рецептор-позитивного) HER2– метастатического рака молочной железы (РМЖ). Как показали результаты проведенных рандомизированных клинических исследований, включение палбоциклиба в различные режимы гормонотерапии HER2– метастатического РМЖ с экспрессией рецепторов эстрогенов позволило существенно улучшить клинические исходы и повысить показатели выживаемости, частоту объективного ответа, его продолжительность и частоту «клинической пользы» (КП). Выигрыш в отношении выживаемости без прогрессирования болезни при добавлении палбоциклиба к летрозолу в 1-й линии гормонотерапии или к фулвестранту у пациенток с прогрессированием на фоне и после предшествующей эндокринной терапии отмечался во всех подгруппах независимо от клинических характеристик, особенностей течения опухолевого процесса, а также экспрессии молекулярных маркеров, опосредующих развитие гормонорезистентности. Основными нежелательными явлениями, связанными с палбоциклибом, были нейтро-, лейкои тромбоцитопения, но в целом гематологическая токсичность была управляемой, а сама терапия безопасной. Эта стратегия, названная экспертами «терапией прорыва», сочетает в себе доказанную эффективность, хорошую переносимость, позволяет поддерживать высокое качество жизни и должна использоваться у больных эстроген-рецептор-позитивным  HER2– метастатическим РМЖ.

Об авторе

Е. В. Артамонова
ФГБУ «НМИЦ онкологии им. Н. Н. Блохина» Минздрава России
Россия

Елена Владимировна Артамонова.

115478, Москва, Каширское шоссе, 23



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Рецензия

Для цитирования:


Артамонова Е.В. ПАЛБОЦИКЛИБ В КОМБИНАЦИИ С ГОРМОНОТЕРАПИЕЙ ПРИ ЛЮМИНАЛЬНОМ HER2-НЕГАТИВНОМ МЕТАСТАТИЧЕСКОМ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ: НОВАЯ ВЫСОКОЭФФЕКТИВНАЯ СТРАТЕГИЯ ЛЕКАРСТВЕННОГО ЛЕЧЕНИЯ. Опухоли женской репродуктивной системы. 2017;13(3):28-40. https://doi.org/10.17650/1994-4098-2017-13-3-28-40

For citation:


Artamonova E.V. PALBOCICLIB IN COMBINATION WITH HORMONE THERAPY FOR LUMINAL HER2-NEGATIVE METASTATIC BREAST CANCER: NEW HIGHLY EFFECTIVE STRATEGY OF DRUG TREATMENT. Tumors of female reproductive system. 2017;13(3):28-40. (In Russ.) https://doi.org/10.17650/1994-4098-2017-13-3-28-40

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ISSN 1994-4098 (Print)
ISSN 1999-8627 (Online)