No 2 (2011)

Different forms of dysplasias that are typical for 20-60% of patients are most frequently recorded among benign breast diseases.
The studies indicate that the rise in benign breast disease morbidity is not accompanied by increased health consciousness and alertness in the female population. 35-39% of women regularly visit a physician; 54-64.2% of women are regularly examined; 22.3% of patients undergo annual breast cancer screening after the age of 40 years. As high as 52-57.1% of women do breast self-exam very month.
At the same time, the timely diagnosis and treatment of benign dysplasias are of great importance due to two main circumstances: 1) the disease development is attended by significant clinical symptomatology that reduces quality of life in women; 2) the proliferative forms of dysplasias are a risk factor for breast cancer.

The paper describes a new class of molecular targeted antitumor agents against the molecules involved in carcinogenesis. It considers the basic drugs of this class and their combinations and evaluates the efficiency of their use in therapy for breast cancer.

Objective: to define a role of magnetic resonance imaging (MRI) in the follow-up of patients with cancer of the cervix uteri (CCU), who have undergone radiation therapy and chemoradiation therapy and to describe the types of the MRI pattern of recurrent CCU in the pelvic region.
Materials and methods. The results of a follow-up of 82 patients with a 4-47- (median 12 months) month history of invasive CCU were analyzed.
Results. Out of the 82 patients with invasive CCU, 25 were found to have pelvic recurrences; in 23 cases MRI revealed the latter (in the cervix uteri (n = 6), corpus uteri (n = 2), vagina (n = 2), parametrium (n = 2), iliac (n = 10), paraaortic (n = 5) lymph nodes, and pelvic wall (n=5).
Conclusion. The findings suggest that pelvic MRI is an effective technique to detect and estimate the extent of a pelvic recurrence and it is expedient to incorporate it into the scope of a follow-up after radiation therapy and chemoradiation therapy in patients with invasive CCU.

Sera from 60 apparently healthy women (mean age 40 years; a control group), 40 patients with a verified diagnosis of adenomyosis (mean age 41 years) and 42 patients with uterine corpus cancer (UCC) (mean age 58 years) were fractionated on magnetic beads with weak cation exchange surface, followed by an examination of the obtained fractions by time-of-flight mass spectroscopy (MS) with ma- trix-activated laser desorption/ionization. MS data analysis using classification algorithms, such as a genetic algorithm and a learning neural network, made it possible to construct mathematical models that were able to differentiate MS profiles of the above sample groups with a high specificity and a high sensitivity. The best values of the specificity and sensitivity of the classification models adenomyosis- control and UCC-control were 86.2, 93.8, 90.5, and 90.5%, respectively. Analysis of the statistical diagrams of these peak areas between different sample groups could identify 3 MS profile peaks for adenomyosis and 3 peaks for UCC.

The problem of ovarian cancer (OC) is considered. The efficiency of multimodality treatment with and without promisan incorporated into its regimen was evaluated in 2 groups of patients with disseminated OC. The efficacy and tolerance of promisan used in patients with disseminated OC are analyzed.
А.В. Жаров, Г.Р. Кравченко, Л.Ф. Чернова, Т.Н. Губайдуллина
Челябинский окружной клинический онкологический диспансер Контакты: Александр Владимирович Жаров roc_chel@mail.ru

The purpose of this study was to estimate the value of and to reveal the specific features of clinical and morphological parameters in pa- tients with vulvar melanoma. The study was based on the data obtained from the analysis of 40 vulvar melanoma patients treated at the N.N. Blokhin Russian Cancer Research Institute in the period January 1980 to December 2010.